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Ana Pombo

  • The living archive
  • How the cell nucleus organizes and controls our genes
  • Geist Heidelberg, In dialogue

Imagine a huge library – not just a storehouse of millions of books, but an active system that decides which book to open and read at any time. This is how our cell nucleus works: two metres of DNA, precisely folded and organized like a living archive.

Ana Pombo and her team have developed groundbreaking methods to visualize the three-dimensional structure of DNA in individual cells. Could decoding this “hidden logic” enable new therapies that reverse pathological cell changes at a very early stage?

Ana Pombo, biochemist and cell biologist, conducts research at the Max Delbrück Center for Molecular Medicine in Berlin and as a professor at Johns Hopkins University in Baltimore. In 2025, she was awarded the Gottfried Wilhelm Leibniz Prize for her groundbreaking research.

Language: English

Foto: Pablo Castagnola / Max Delbrück Center

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